CNS monoamine levels and motoric behaviors in the hotfoot ataxic mutant.

@article{Draski1994CNSML,
  title={CNS monoamine levels and motoric behaviors in the hotfoot ataxic mutant.},
  author={Laura Draski and David J Nash and Greg A. Gerhardt},
  journal={Brain research},
  year={1994},
  volume={645 1-2},
  pages={69-77}
}
Mice that were homozygous recessive for the single-gene mutation, hotfoot, showed profound and progressive motor disturbances in an open field after approximately the 4th postnatal week. Studies were undertaken to examine the role of the monoaminergic system in the behavioral and developmental expression of this neurological mutation. Relative to controls, 10-and 30-day-old hotfoot mice demonstrated a significantly attenuated response to the stimulating locomotor effects of amphetamine while… CONTINUE READING