CNS leptin and insulin action in the control of energy homeostasis.

@article{Belgardt2010CNSLA,
  title={CNS leptin and insulin action in the control of energy homeostasis.},
  author={Bengt F. Belgardt and Jens C. Br{\"u}ning},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1212},
  pages={
          97-113
        }
}
The obesity and diabetes pandemics have made it an urgent necessity to define the central nervous system (CNS) pathways controlling body weight, energy expenditure, and fuel metabolism. The pancreatic hormone insulin and the adipose tissue-derived leptin are known to act on diverse neuronal circuits in the CNS to maintain body weight and metabolism in a variety of species, including humans. Because these homeostatic circuits are disrupted during the development of obesity, the pathomechanisms… CONTINUE READING
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