CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection

@article{FischerSmith2001CNSIB,
  title={CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection},
  author={Tracy Fischer-Smith and Sidney Croul and Andrij E. Sverstiuk and Christelle Capini and Darryl Z. L'Heureux and Emmanuel G. Regulier and Max W. Richardson and Shohreh Amini and Susan Morgello and Kamel Khalili and Jay Rappaport},
  journal={Journal of NeuroVirology},
  year={2001},
  volume={7},
  pages={528-541}
}
  • Tracy Fischer-Smith, Sidney Croul, +8 authors Jay Rappaport
  • Published in Journal of NeuroVirology 2001
  • DOI:10.1080/135502801753248114
Increases in circulating CD14+/CD16+ monocytes have been associated with HIV dementia; trafficking of these cells into the CNS has been proposed to play an important role in the pathogenesis of HIV-induced neurological disorders. This model suggests that events outside the CNS leading to monocyte activation initiate the process leading to HIV dementia. To investigate the role of this activated monocyte subset in the pathogenesis of HIV dementia, we examined brain specimens from patients with… CONTINUE READING

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