CNS inflammation : mechanisms of damage and strategies for prevention

  title={CNS inflammation : mechanisms of damage and strategies for prevention},
  author={B. Zhu},
  • B. Zhu
  • Published 2002
  • Medicine
  • Axonal damage in the central nervous system (CNS) is an important pathological process in multiple sclerosis (MS). I established an acute demyelination model in the rat optic nerve through the microinjection of anti-galactocerebroside antibody and complement. Neurofilament.(NF) and microtubule (MT) immunoreactivity was markedly reduced within large demyelination lesions that had little inflammation at 24 hours after the injection. Between 3 and 7 days post-injection, there was a gradual… CONTINUE READING


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