CNS immune privilege: hiding in plain sight.

@article{Carson2006CNSIP,
  title={CNS immune privilege: hiding in plain sight.},
  author={Monica J. Carson and Jonathan M. Doose and Beno{\^i}t Melchior and Christoph D. Schmid and Corinne C Ploix},
  journal={Immunological reviews},
  year={2006},
  volume={213},
  pages={48-65}
}
Central nervous system (CNS) immune privilege is an experimentally defined phenomenon. Tissues that are rapidly rejected by the immune system when grafted in sites, such as the skin, show prolonged survival when grafted into the CNS. Initially, CNS immune privilege was construed as CNS isolation from the immune system by the blood-brain barrier (BBB), the lack of draining lymphatics, and the apparent immunoincompetence of microglia, the resident CNS macrophage. CNS autoimmunity and… CONTINUE READING
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