CNS changes in hyperbilirubinemia. Functional implications.

  title={CNS changes in hyperbilirubinemia. Functional implications.},
  author={Jean Y. Jew and Dean Sandquist},
  journal={Archives of neurology},
  volume={36 3},
Hyperbilirubinemia is a recognized etiologic factor in motor and hearing disorders associated with cerebral palsy. Its role in more subtle forms of neurological impairment is more controversial. Using a mutant animal model, which develops symptoms and signs closely resembling the human kernicterus syndrome, neurons of hippocampus, cerebral cortex, cochlear nuclei, losuc ceruleus, and olfactory bulb were examined by electron microscopy. Pathological changes, observed in all areas studied… CONTINUE READING