CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands.

@article{Chattopadhyay2004CNSAO,
  title={CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands.},
  author={Debprasad Chattopadhyay and Ganeshan Arunachalam and Lopamudra Ghosh and Asit Baran Mandal},
  journal={Fitoterapia},
  year={2004},
  volume={75 7-8},
  pages={673-82}
}
Methanol extract at 100-200 mg/kg p.o. and major nonpolar fraction B at 50 mg/kg of Alstonia macrophylla leaves caused a significant reduction in spontaneous activity, remarkable decrease in exploratory behavioural pattern, a reduction in muscle relaxant activity and also significantly potentiated phenobarbitone sodium-induced sleeping time. The phytochemical study of crude leaf extract revealed the presence of tannin, triterpenoid, flavonoid, sterol, alkaloid and reducing sugars. Further… CONTINUE READING