CNS Schwann-like glia and functional restoration of damaged spinal cord.

  title={CNS Schwann-like glia and functional restoration of damaged spinal cord.},
  author={Manuel Nieto‐Sampedro},
  journal={Progress in brain research},
Publisher Summary The chapter discusses the four complementary aspects of the central nervous system (CNS) lesion repair problem, in order to show: (1) neurotrophic and neuritogenic activities expressed in brain and spinal cord under normal circumstances are up-regulated after injury; (2) the concentration of neurite inhibitors in normal brain also increases after injury; (3) glioblast division inhibitors exist in normal CNS and that their concentration decreases after injury; and (4) Schwann… Expand
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Olfactory bulb implantation and methylprednisolone administration in the treatment of spinal cord injury in rats
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In vitro susceptibility of glial cells obtained from the adult canine brain for different strains of canine distemper virus
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This work focuses on repair after Spinal Cord Injury, and the role of Macrophages in Degeneration and Regeneration in the Peripheral Nervous System. Expand
Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors
The capacity for CNS axons to regenerate and elongate within differentiated CNS tissue after the neutralization of myelin-associated neurite growth inhibitors is demonstrated. Expand
Neurite outgrowth over resting and reactive astrocytes.
Observations suggest that reactive astrocytes are still the major problem for axonal regeneration in the CNS, and reactive glia seem to contain both inhibitory and neurite promoting molecules, the proportion of which depends on the way gliosis has been generated. Expand
Functional regeneration of sensory axons into the adult spinal cord
It is shown that, with trophic support to damaged sensory axons, this regenerative barrier is surmountable and neurotrophic factor treatment may serve as a viable treatment in promoting recovery from root avulsion injuries. Expand
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST, and application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres. Expand
The transitional zone and CNS regeneration
  • J. Fraher
  • Biology, Medicine
  • Journal of anatomy
  • 2000
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Axons from CNS neurones regenerate into PNS grafts
The capacity of transected axons originating in the CNS to regrow into nerve grafts containing Schwann cells is examined and it is found that these axonal sprouts form sprouts after injury in mammals and some fish and amphibians. Expand
Glial influences on axonal growth in the primary olfactory system
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Regeneration into the Spinal Cord of Transected Dorsal Root Axons Is Promoted by Ensheathing Glia Transplants
The regeneration of injured dorsal root axons into the adult spinal cord was possible after ensheathing glia transplantation, and the use of ens heathing cells as stimulators of axonal growth might be generalized to other central nervous system injuries. Expand
Spinal Cord Reconstruction
This article provides a clear example of regeneration, associated with functional restoration, in a mammalian model of spinal cord injury in humans, using intercostal nerve gnfts that redirected axons from white matter (containing molecules that inhibit axonal regeneration) to gray matter. Expand