CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease

@inproceedings{Weir2012CNSSE,
  title={CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease},
  author={Heather J. M. Weir and Tracey K. Murray and Patrick Gavin Kehoe and Seth Love and Eric Verdin and Michael J. O’Neill and Jon D Lane and Nina Balthasar},
  booktitle={PloS one},
  year={2012}
}
Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial responses to reactive oxygen species (ROS)- and Alzheimer's disease (AD)-mediated stress. Pharmacological augmentation of mitochondrial ROS increases Sirt3 expression in primary hippocampal culture with SIRT3 over-expression being neuroprotective… CONTINUE READING