CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice

@article{Gow1999CNSMA,
  title={CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice},
  author={Alexander Gow and Cherie M Southwood and Jing Li and Milena Pariali and Gavin P. Riordan and Scott E. Brodie and John Danias and Jeff M. Bronstein and Bechara Kachar and Robert A. Lazzarini},
  journal={Cell},
  year={1999},
  volume={99},
  pages={649-659}
}
Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and males are sterile. Freeze fracture reveals that tight junction intramembranous strands are absent in CNS myelin and between Sertoli cells of mutant mice. Our results demonstrate that… CONTINUE READING
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