CNS Adverse Events Associated With Antimalarial Agents

  title={CNS Adverse Events Associated With Antimalarial Agents},
  author={P. A. Phillips-Howard and F. Kuile},
  journal={Drug Safety},
  • P. A. Phillips-Howard, F. Kuile
  • Published 1995
  • Medicine
  • Drug Safety
  • SummaryCNS adverse drug events are dramatic, and case reports have influenced clinical opinion on the use of antimalarials. Malaria also causes CNS symptoms, thus establishing causality is difficult.CNS events are associated with the quinoline and artemisinin derivatives. Chloroquine, once considered too toxic for humans, has been the antimalarial of choice for 40 years. While a range of serious CNS effects have been documented during chloroquine therapy, the incidence is unclear… CONTINUE READING
    139 Citations
    Antimalarial Drug Toxicity: A Review
    • 298
    Safety evaluation of the drugs available to prevent malaria
    • 28
    Serious adverse events of mefloquine in relation to blood level and gender.
    • 46
    • PDF
    Antimalarial Drug Toxicity
    • 292
    • PDF
    Mefloquine for malaria chemoprophylaxis 1992-1998: a review.
    • 103
    • PDF
    Mefloquine for preventing malaria in non-immune adult travellers.
    • 29


    Clinical Features and Management of Poisoning due to Antimalarial Drugs
    • 100
    Adverse reactions to sulfa drugs: implications for malaria chemotherapy.
    • 61
    • PDF
    Neurotoxicity in animals due to arteether and artemether.
    • 238
    • PDF
    Chloroquine seizures. Report of four cases.
    • 21
    Clinical experience with halofantrine in the treatment of malaria.
    • 20