CNR1 variation modulates risk for drug and alcohol dependence.

  title={CNR1 variation modulates risk for drug and alcohol dependence.},
  author={Lingjun Zuo and Henry R. Kranzler and Xingguang Luo and Jonathan Covault and Joel Gelernter},
  journal={Biological psychiatry},
  volume={62 6},
BACKGROUND Human cannabinoid receptor 1 (CB1), which is encoded by the CNR1 gene, may play a role in the development of substance dependence (SD). Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample. METHODS Ten CNR1 markers and 38 ancestry-informative markers were genotyped in 451 healthy control subjects and 550 SD (AD and/or DD) patients (including European Americans [EAs] and African Americans [AAs]). Common… CONTINUE READING


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