CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells

@inproceedings{Ito2018CNPY2IM,
  title={CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells},
  author={Saya Ito and Akihisa Ueno and Takashi Ueda and Hideo Nakagawa and Hidefumi Taniguchi and Naruhiro Kayukawa and Atsuko Fujihara-Iwata and Fumiya Hongo and Koji Okihara and Osamu Ukimura},
  booktitle={Oncotarget},
  year={2018}
}
The androgen receptor (AR) is a ligand-dependent transcription factor that promotes prostate cancer (PC) cell growth through control of target gene expression. This report suggests that Canopy FGF signaling regulator 2 (CNPY2) controls AR protein levels in PC cells. We found that AR was ubiquitinated by an E3 ubiquitin ligase, myosin regulatory light chain interacting protein (MYLIP) and then degraded through the ubiquitin-proteasome pathway. CNPY2 decreased the ubiquitination activity of MYLIP… CONTINUE READING

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