CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.

Abstract

PURPOSE To investigate rod function and survival after cone dysfunction and degeneration in a mouse model of cone cyclic nucleotide-gated (CNG) channel deficiency. METHODS Rod function and survival in mice with cone CNG channel subunit CNGA3 deficiency (CNGA3-/- mice) were evaluated by electroretinographic (ERG), morphometric, and Western blot analyses… (More)
DOI: 10.1167/iovs.11-8168

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Cite this paper

@article{Xu2012CNGA3DA, title={CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.}, author={Jianhua Xu and Lynsie M. Morris and Stylianos Michalakis and Martin Biel and Steven J. Fliesler and David M. Sherry and Xi-Qin Ding}, journal={Investigative ophthalmology & visual science}, year={2012}, volume={53 3}, pages={1117-29} }