CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.

@article{Roux2013CMVDC,
  title={CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.},
  author={Antoine Roux and Gis{\'e}le Mourin and Sol{\`e}ne Fastenackels and Jorge S{\'a}nchez Almeida and Maria Candela Iglesias and A Boyd and Emma Gostick and Martin Larsen and David A. Price and Karim Sacr{\'e} and Daniel C. Douek and Brigitte Autran and Cl{\'e}ment Picard and Sandra Marina Ribeiro de Miranda and Delphine Sauce and Marc Stern and Victor Appay},
  journal={Clinical immunology},
  year={2013},
  volume={148 1},
  pages={16-26}
}
Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence of acute lung rejection and cytomegalovirus infection. However, the reasons for this association remain unclear. Here, we performed a longitudinal characterization of CMV-specific T-cell responses and… CONTINUE READING