CMV Primary Infection Is Associated With Donor‐Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation

@article{Shi2015CMVPI,
  title={CMV Primary Infection Is Associated With Donor‐Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation},
  author={X.L. Shi and E L D de Mare-Bredemeijer and {\"O}zlem Tapirdamaz and Bettina E Hansen and Rogier van Gent and Margo J H van Campenhout and Shanta Mancham and Nicolle H. R. Litjens and Michiel G H Betjes and Annemiek A. van der Eijk and Q. Xia and Luc J.W. van der Laan and Jeroen de Jonge and Herold Johnny Metselaar and Jaap Kwekkeboom},
  journal={American Journal of Transplantation},
  year={2015},
  volume={15}
}
Viral infections, including cytomegalovirus (CMV), abrogate transplantation tolerance in animal models. Whether this also occurs in humans remains elusive. We investigated how CMV affects T cells and rejection episodes after liver transplantation (LT). Phenotype and alloreactivity of peripheral and allograft‐infiltrating T cells from LT patients with different CMV status were analyzed by flow cytometry. The association of CMV status with early and late acute rejection was retrospectively… 
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References

SHOWING 1-10 OF 50 REFERENCES
T-Cell Immunity to Subclinical Cytomegalovirus Infection Reduces Cardiac Allograft Disease
TLDR
The early control of subclinical CMV replication after transplantation by T-cell immunity may limit cardiac allograft rejection and vascular disease.
High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function.
Disruption of Murine Cardiac Allograft Acceptance by Latent Cytomegalovirus
  • C. Cook, A. Bickerstaff, C. Orosz
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2009
TLDR
It is suggested that transplantation in an environment of latent CMV infection may reactivate virus, and that intragraft responses disrupt development of allograft acceptance.
Long-term expansion of effector/memory Vdelta2-gammadelta T cells is a specific blood signature of CMV infection.
TLDR
The increased level of effector-memory Vdelta2- gammadelta T cells in the peripheral blood is a specific signature of an adaptive immune response to CMV infection of both immunocompetent and immunosuppressed patients.
Terminally Differentiated CD8+ Temra Cells Are Associated With the Risk for Acute Kidney Allograft Rejection
TLDR
Advanced ESRD-related T-cell dysregulation that is associated with a relative increase of terminally differentiated CD8+ Temra cells protects against AR after kidney transplantation.
Long-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation
TLDR
Findings provide evidence that T-cell skewing toward TEM may be associated with antigraft reactivity long after lymphodepletion, and further testing of TEM and TEMRA subsets as rejection predictors is warranted.
Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs.
TLDR
Recently developed therapeutic strategies to promote tolerance to transplanted livers and other organs and diagnostic tools that might be used to identify patients most likely to accept or reject allografts are reviewed.
Analyses of Peripheral Blood Mononuclear Cells in Operational Tolerance After Pediatric Living Donor Liver Transplantation
  • Ying Li, T. Koshiba, Koichi Tanaka
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2004
TLDR
Systemically phenotyped peripheral blood mononuclear cells from operationally tolerant patients to provide important clues for reliable indicators of tolerance after LDLT and the contribution of those subsets to the tolerant state remains elusive.
Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation
  • B. Bosma, H. Metselaar, J. Kwekkeboom
  • Medicine, Biology
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2010
TLDR
MDCs detaching from liver grafts produce pro‐inflammatory and anti‐inflammatory cytokines and are capable of stimulating allogeneic T helper 1 responses, and this suggests that MDC chimerism after clinical LTx may contribute to liver graft rejection rather than acceptance.
...
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