CMV Primary Infection Is Associated With Donor‐Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation

@article{Shi2015CMVPI,
  title={CMV Primary Infection Is Associated With Donor‐Specific T Cell Hyporesponsiveness and Fewer Late Acute Rejections After Liver Transplantation},
  author={X-L Shi and E. L. D. de Mare-Bredemeijer and {\"O}. Tapirdamaz and B. Hansen and R. van Gent and M. J. V. van Campenhout and S. Mancham and N. Litjens and M. Betjes and A. A. van der Eijk and Q. Xia and L. V. D. van der Laan and J. de Jonge and H. Metselaar and J. Kwekkeboom},
  journal={American Journal of Transplantation},
  year={2015},
  volume={15}
}
Viral infections, including cytomegalovirus (CMV), abrogate transplantation tolerance in animal models. Whether this also occurs in humans remains elusive. We investigated how CMV affects T cells and rejection episodes after liver transplantation (LT). Phenotype and alloreactivity of peripheral and allograft‐infiltrating T cells from LT patients with different CMV status were analyzed by flow cytometry. The association of CMV status with early and late acute rejection was retrospectively… Expand
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