CMOS Low Current Measurement System for Biomedical Applications

@article{Goldstein2011CMOSLC,
  title={CMOS Low Current Measurement System for Biomedical Applications},
  author={Brian Goldstein and Dongsoo Kim and Jian Xu and T. Kyle Vanderlick and Eugenio Culurciello},
  journal={IEEE Transactions on Biomedical Circuits and Systems},
  year={2011},
  volume={6},
  pages={111-119}
}
We present a micro-chip implementation of a low current measurement system for biomedical applications using capacitive feedback that exhibits 190 fA of RMS noise in a 1 kHz bandwidth. The sampling rate is selectable up to 100 kHz. When measuring the amplifier noise with a 10 G Ω resistor and a 47 pF capacitor at the input, typical of cell membrane capacitance in DNA and patch clamp experiments, the measured RMS noise was 2.44 pA on a 50 pA signal in a 10 kHz bandwidth. Two channels were… CONTINUE READING

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