CML patients in blast crisis have breakpoints localized to a specific region of the BCR.

@article{SchaeferRego1987CMLPI,
  title={CML patients in blast crisis have breakpoints localized to a specific region of the BCR.},
  author={K E Schaefer-Rego and Henryk Dudek and D W Popenoe and Zalmen A. Arlin and John Gregory Mears and Allan Bank and David Leibowitz},
  journal={Blood},
  year={1987},
  volume={70 2},
  pages={448-55}
}
Chronic myelogenous leukemia (CML) is associated with the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between chromosomes 9 and 22. This activates the abl oncogene by moving it from chromosome 9 and combining it with sequence located on chromosome 22. The new fusion gene, with chromosome 22 sequence at its 5' end and chromosome 9-abl sequence at its 3' end, generates a new messenger RNA (mRNA) and protein that are implicated in the pathogenesis of CML. The… CONTINUE READING