- R. L. CLANCY, W.A.F. TOMKINS, T. J. MUCKLE, H. RICHARDSON, W. E. RAWLS
- med. I. iii, 568.
IN 1907, at the 10110S Hopkins Hospital, an autopsy was performed by Whipple on a doctor colleague who had died following a protracted wasting illness. As a result he published the first account of the disease which bears his name (Whipple 1907). It is an uncommon disorder characteriscd by diarrhoea, strealorrhea, loss of weight. anaemia, arthralgia and skin pigmentation. Whipple described an intense accumulation of fat within the intestinal mucosa and coined the descriptive name 'intestinal lipodystrophy'. Black-Schaffer (1949), using light microscopy, first demonstrated within the mucosa of the small intestine an intense infiltration with macro phages containing granules which stain strongly by the periodic acid-SchifT (PAS) method.