CLUE: Exact maximal reduction of kinetic models by constrained lumping of differential equations

  title={CLUE: Exact maximal reduction of kinetic models by constrained lumping of differential equations},
  author={Alexey Ovchinnikov and Isabel Christina P{\'e}rez-Verona and Gleb Pogudin and Mirco Tribastone},
MOTIVATION Detailed mechanistic models of biological processes can pose significant challenges for analysis and parameter estimations due to the large number of equations used to track the dynamics of all distinct configurations in which each involved biochemical species can be found. Model reduction can help tame such complexity by providing a lower-dimensional model in which each macro-variable can be directly related to the original variables. RESULTS We present CLUE, an algorithm for… 

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