CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques

APOE is the strongest risk gene for sporadic Alzheimer's disease (AD) so far. Recent genome wide association studies found links for sporadic AD with CLU and CR1 involved in Aβ clearance, and PICALM affecting intracellular trafficking. We investigated the associations of senile plaques (SP) and neurofibrillary tangles (NFT) with the proposed risk genes and… CONTINUE READING