author={Juhana E. Id{\"a}np{\"a}{\"a}n-Heikkil{\"a} and Eeva Alhava and Martti Olkinuora and Ilmari Palva},
  journal={The Lancet},

Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study

A genome-wide association study in a Chinese population provides novel and valuable understanding of the genetic and immune causes of CIL and CIN, which is useful for improving clinical management of clozapine related treatment for schizophrenia.

Dopamine and Response to Antipsychotic Medication

Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety—Particularities in the Context of COVID-19

Clozapine doses should be personalized for each patient based on pharmacogenetics testing when available and the genetic vulnerability postulates predictors of adverse reactions’ severity; patients with a lower genetic risk could have less frequent hematological monitoring.

Neutrophil fluorescence in clozapine users is attributable to a 14kDa secretable protein

Clozapine‐associated fluorescence in neutrophils is originating from a 14kDa soluble protein (fragment) present in azurophilic granules of neutrophil, and the identity of this protein and its potential role in the pathophysiology of clozAPine‐induced agranulocytosis is explored.



Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome.

The role of the neoplasm in the development ofThe nephrotic syndrome can be attributed in some cases to obvio...

Acute Paracetamol Poisoning

Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of

Acute liver necrosis following overdose of paracetamol.

A woman aged 30, an inmate of a mental institution, was admitted to hospital two hours after ingesting at least 50 paracetamol tablets, and gastric lavage was carried out almost immediately.