author={Robert W. Griffith and K. Saameli},
  journal={The Lancet},

Agranulocytosis during treatment with clozapine

Within six months of the introduction of the new antipsychotic drug clozapine in Finland, 17 cases of neutropenia or agranulocytosis were recorded amongst about 3000 patients treated, with a high incidence of complications.

Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study

A genome-wide association study in a Chinese population provides novel and valuable understanding of the genetic and immune causes of CIL and CIN, which is useful for improving clinical management of clozapine related treatment for schizophrenia.

Predictors of dopamine agonist resistance in prolactinoma patients

Predictive factors for pharmacological resistance and a scoring system for patient specific prediction of resistance to dopamine agonists are identified and developed and may have impact on the timing and decision of surgery in prolactinoma patients after further prospective evaluation.

Prevalence of molecular markers associated with drug resistance of Plasmodium vivax isolates in Western Yunnan Province, China

There was moderate diversity of molecular patterns of resistance markers of Pvdhfr, Pvdhps, Pvmdr1 and Pvcrt-o in imported P. vivax cases to Yingjiang county in Western Yunnan, along the China–Myanmar border, which would help to update drug policy.

Molecular characterization of Plasmodium falciparum antifolate resistance markers in Thailand between 2008 and 2016

Despite withdrawal of SP as anti-malarial treatment for 17 years, the border regions of Thailand continue to display high prevalence of antifolate and anti-sulfonamide resistance markers in falciparum malaria.

Molecular surveillance of Pfcrt and k13 propeller polymorphisms of imported Plasmodium falciparum cases to Zhejiang Province, China between 2016 and 2018

The frequency and spatial distributions of Pfcrt and k13 mutations associated with drug resistance were determined and the genetic diversity of k13 was low in most regions of Africa and purifying selection was suggested by Tajima’s D test.

Surgery for prolactinomas: a better choice?

Given excellent results of TSS and concerns about medical treatment, the scale of indications for TSS as an alternative to DAs has increased and the patient’s wishes concerning a chance at a cure with TSS instead of a long-term treatment with DAs have become an important and accepted indication.

Clinical and laboratory characteristics of clozapine treated schizophrenia patients referred to a national immunodeficiency clinic reveals a B-cell signature resembling CVID.

These individuals displayed clinical patterns closely resembling the primary immunodeficiency CVID, however appears reversible upon drug cessation, which has diagnostic, monitoring and treatment implications for psychiatry and immunology teams and directs prospective studies to address causality.

The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies

The prevalence of clozapine-associated agranulocytosis is low and agranulocyTosis-related death appears rare, and the findings are consistent with previous findings.

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective

An overview of the current understanding of the genetics of clozapine-associated agranulocytosis and neutropenia is provided and recent findings relating to the Duffy-null genotype and its association with benign neutropania in individuals with African ancestry are described.



A Series of New Screening Procedures for Pyruvate Kinase Deficiency, Glucose-6-Phosphate Dehydrogenase Deficiency, and Glutathione Reductase Deficiency

A new type of screening procedure for the detection of enzymatic defects of the red cell has been described, and the same general procedure should be readily adaptable to the Detection of other enzyme deficiencies of red cells, such as phosphogluconate dehydrogenase deficiency or triosephosphate isomerase deficiency.

Agranulocytosis, leukopenia, and psychotropic drugs.

The medical staff should be on the alert for evidence of infection in patients taking psychotropic drugs so that laboratory tests can be ordered if indicated by current symptoms or a history suggesting a high risk of infection.

Agranulocytosis induced by certain phenothiazine derivatives.

Clinical and hematologic characteristics of Phenothiazine-induced agranulocytosis suggest that the mechanisms underlying the development of this condition are related to a possible suppressive effect of phenothiazines on cell division.

Diagnosis of erythrocyte glucose-6-phosphate dehydrogenase deficiency in the negro male despite hemolytic crisis.

By measuring enzyme activity in the persisting older erythrocytes, the deficiency can be recognized without having to wait until the hemolytic episode and its reticulocyte response have subsided.

A tetrazolium-linked cytochemical method for estimation of glucose-6-phosphate dehydrogenase activity in individual erythrocytes: applications in the study of heterozygotes for glucose-6-phosphate dehydrogenase deficiency.

A new method is described that appears to be more sensitive than conventional methods for identification of women heterozygous for G6PD deficiency and further substantiates the existence of erythrocyte mosaicism in such individuals.