CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients

@article{Kishi2009CLOCKMP,
  title={CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients},
  author={Taro Kishi and Tsuyoshi Kitajima and M Ikeda and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Tomo Okochi and Takenori Okumura and Tomoko Tsunoka and Norio Ozaki and Nakao Iwata},
  journal={NeuroMolecular Medicine},
  year={2009},
  volume={11},
  pages={53-57}
}
Recent studies have shown that selective serotonin reuptake inhibitors (SSRIs) have circadian properties, suggesting that the antidepressive action of SSRIs may also be attributable to circadian mechanisms. Another study reported an association between clock gene (CLOCK) and improvements in insomnia symptoms from SSRIs treatment. Therefore, we examined the association between CLOCK and the efficacy of fluvoxamine treatment in 121 patients with Japanese major depressive disorder (MDD). The MDD… CONTINUE READING
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