CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression.

@article{Oishi2006CLOCKII,
  title={CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression.},
  author={Katsutaka Oishi and Naoki Ohkura and Miyuki Wakabayashi and Hidenori Shirai and Keizo Sato and Juzo Matsuda and G Atsumi and Norio Ishida},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2006},
  volume={4 8},
  pages={1774-80}
}
BACKGROUND An increased level of obesity-induced plasma plasminogen activator inhibitor-1 (PAI-1) is considered a risk factor for cardiovascular disease. AIM The present study investigates whether the circadian clock component CLOCK is involved in obesity-induced PAI-1 elevation. METHODS We examined plasma PAI-1 and mRNA expression levels in tissues from leptin-deficient obese and diabetic ob/ob mice lacking functional CLOCK protein. RESULTS Our results demonstrated that plasma PAI-1… CONTINUE READING

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