CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α

@article{Li2013CLOCKIA,
  title={CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α},
  author={Shuo Li and M Wang and Xiang Ao and Alan Kuei-Chieh Chang and Chun-Yuh Yang and Fangping Zhao and Huaqiang Bi and Yu Liu and Ling Xiao and H Wu},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={4883-4891}
}
Disruption of the circadian rhythm is now believed to associate with a number of hormone-related cancers, such as breast cancer, in which aberrant estrogen receptor-α (ERα) signaling is a major contributor. However, the molecular mechanisms underlying the function of core clock proteins in cancer are still largely undefined. In this study, we showed that circadian locomotor output cycles kaput (CLOCK), a key circadian protein, can interact with ERα. Furthermore, this interaction was enhanced by… CONTINUE READING
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The transcriptional activity of coactivator AIB 1 is regulated by the SUMO E 3 Ligase PIAS 1

S Li, C Yang, +3 authors Y Liu
Biol Cell • 2012

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