CLOCK gene variants associate with sleep duration in two independent populations.

  title={CLOCK gene variants associate with sleep duration in two independent populations.},
  author={Karla Viviani Allebrandt and Maris Teder-Laving and Mahmut Akyol and Irene Pichler and Bertram M{\"u}ller-Myhsok and Peter P. Pramstaller and Martha Merrow and Thomas Meitinger and Andreas Metspalu and Till Roenneberg},
  journal={Biological psychiatry},
  volume={67 11},
BACKGROUND Sleep is an active and complex behavior, yet it has two straightforward properties-timing and duration. Clock genes are associated with dysfunctional timing of sleep, mood, and obesity disorders, which are commonly associated with sleep duration. METHODS Sleep duration was assessed in Central Europe, Estonia, and South Tyrol (n approximately 77,000) with the Munich ChronoType Questionnaire. It showed a Gaussian distribution in all investigated populations after averaging over a… CONTINUE READING


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Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2008

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