CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila.

@article{Luo2012CLOCKDB,
  title={CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila.},
  author={Weifei Luo and Yue Li and Chih-Hang Anthony Tang and Katharine C Abruzzi and Joseph M. Tortes i Rodriguez and Stefan Pescatore and Michael Rosbash},
  journal={Genes & development},
  year={2012},
  volume={26 22},
  pages={2536-49}
}
A conserved transcriptional feedback loop underlies animal circadian rhythms. In Drosophila, the transcription factors CLOCK (CLK) and CYCLE (CYC) activate the transcription of direct target genes like period (per) and timeless (tim). They encode the proteins PER and TIM, respectively, which repress CLK/CYC activity. Previous work indicates that repression is due to a direct PER-CLK/CYC interaction as well as CLK/CYC phosphorylation. We describe here the role of ubiquitin-specific protease 8… CONTINUE READING
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