CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors.

@article{Haque2010CLOCKAN,
  title={CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors.},
  author={Rashidul Haque and Fatima G Ali and Rebecca Biscoglia and Jane Abey and Joan Weller and David Klein and Paul Michael Iuvone},
  journal={Journal of neurochemistry},
  year={2010},
  volume={113 5},
  pages={1296-306}
}
Circadian clocks in vertebrates are thought to be composed of transcriptional-translational feedback loops involving a highly conversed set of 'clock genes' namely, period (Per1-3) and cryptochrome (Cry1-2), which encode negative transcriptional regulators; and Bmal1, Clock, and Npas2, which encode positive regulators. Aanat, which encodes arylalkylamine N-acetyltransferase (AANAT), the key regulatory enzyme that drives the circadian rhythm of melatonin synthesis, contains a circadian E-box… CONTINUE READING

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