CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide.

@article{Puranam1999CLN3DA,
  title={CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide.},
  author={Kasturi Lahiri Puranam and Weinong Guo and Wen Hua Qian and K N Nikbakht and R M Boustany},
  journal={Molecular genetics and metabolism},
  year={1999},
  volume={66 4},
  pages={294-308}
}
Juvenile neuronal ceroid lipofuscinosis or Batten disease (JNCL) is a neurodegenerative disorder characterized by blindness, seizures, cognitive decline and early death. Brain atrophy and retinitis pigmentosa ensue because of neuronal and photoreceptor apoptosis. The CLN3 gene defective in JNCL encodes a novel 438 amino acid protein. Most affected genes… CONTINUE READING