CLIP identifies Nova-regulated RNA networks in the brain.

  title={CLIP identifies Nova-regulated RNA networks in the brain.},
  author={Ule Jernej and Kirk B. Jensen and Matteo Ruggiu and Aldo Mele and Aljaz Ule and Robert B Darnell},
  volume={302 5648},
Nova proteins are neuron-specific antigens targeted in paraneoplastic opsoclonus myoclonus ataxia (POMA), an autoimmune neurologic disease characterized by abnormal motor inhibition. Nova proteins regulate neuronal pre-messenger RNA splicing by directly binding to RNA. To identify Nova RNA targets, we developed a method to purify protein-RNA complexes from mouse brain with the use of ultraviolet cross-linking and immunoprecipitation (CLIP).Thirty-four transcripts were identified multiple times… CONTINUE READING
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