CLIP-based prediction of mammalian microRNA binding sites

  title={CLIP-based prediction of mammalian microRNA binding sites},
  author={Chaochun Liu and Bibekanand Mallick and Dang D. Long and William A. Rennie and Adam Wolenc and C. Steven Carmack and Ye Ding},
  booktitle={Nucleic acids research},
Prediction and validation of microRNA (miRNA) targets are essential for understanding functions of miRNAs in gene regulation. Crosslinking immunoprecipitation (CLIP) allows direct identification of a huge number of Argonaute-bound target sequences that contain miRNA binding sites. By analysing data from CLIP studies, we identified a comprehensive list of sequence, thermodynamic and target structure features that are essential for target binding by miRNAs in the 3' untranslated region (3' UTR… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 45 references

MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA

J. Wen, B. J. Parker, A. Jacobsen, A. Krogh
action. RNA, • 2011

Similar Papers

Loading similar papers…