CLIP-based prediction of mammalian microRNA binding sites

@inproceedings{Liu2013CLIPbasedPO,
  title={CLIP-based prediction of mammalian microRNA binding sites},
  author={Chaochun Liu and Bibekanand Mallick and Dang D. Long and William A. Rennie and Adam Wolenc and C. Steven Carmack and Ye Ding},
  booktitle={Nucleic acids research},
  year={2013}
}
Prediction and validation of microRNA (miRNA) targets are essential for understanding functions of miRNAs in gene regulation. Crosslinking immunoprecipitation (CLIP) allows direct identification of a huge number of Argonaute-bound target sequences that contain miRNA binding sites. By analysing data from CLIP studies, we identified a comprehensive list of sequence, thermodynamic and target structure features that are essential for target binding by miRNAs in the 3' untranslated region (3' UTR… CONTINUE READING
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J. Wen, B. J. Parker, A. Jacobsen, A. Krogh
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