CLIC4 regulates TGF-β dependent myofibroblast differentiation to produce a cancer stroma

  title={CLIC4 regulates TGF-β dependent myofibroblast differentiation to produce a cancer stroma},
  author={Anjali Shukla and Robert Edwards and Yili Yang and ANDPAULF. HAHN and K Folkers and Jinhui Ding and V C Padmakumar and Christophe Cataisson and KS Suh and S H Yuspa},
Cancer stroma has a profound influence on tumor development and progression. The conversion of fibroblasts to activated myofibroblasts is a hallmark of reactive tumor stroma. Among a number of factors involved in this conversion, transforming growth factor (TGF)-β has emerged as a major regulator. CLIC4, an integral protein in TGF-β signaling, is highly upregulated in stroma of multiple human cancers, and overexpression of CLIC4 in stromal cells enhances the growth of cancer xenografts. In this… CONTINUE READING


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