CLEC5A is critical for dengue-virus-induced lethal disease

  title={CLEC5A is critical for dengue-virus-induced lethal disease},
  author={Szu-Ting Chen and Yi-Ling Lin and Ming-Ting Huang and Ming-Fang Wu and Shih-Chin Cheng and Huan-Yao Lei and Chien-Kuo Lee and T. W. Chiou and Chi‐Huey Wong and Shie-Liang Hsieh},
Dengue haemorrhagic fever and dengue shock syndrome, the most severe responses to dengue virus (DV) infection, are characterized by plasma leakage (due to increased vascular permeability) and low platelet counts. CLEC5A (C-type lectin domain family 5, member A; also known as myeloid DAP12-associating lectin (MDL-1)) contains a C-type lectin-like fold similar to the natural-killer T-cell C-type lectin domains and associates with a 12-kDa DNAX-activating protein (DAP12) on myeloid cells. Here we… 

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