CLEC-2 is required for development and maintenance of lymph nodes.

@article{Bnzech2014CLEC2IR,
  title={CLEC-2 is required for development and maintenance of lymph nodes.},
  author={C{\'e}cile B{\'e}n{\'e}zech and Saba Nayar and Brenda A. Finney and David R Withers and Kate Lowe and Guillaume Desanti and Clare L. Marriott and Steve P Watson and Jorge H Caama{\~n}o and Christopher D Buckley and Francesca Barone},
  journal={Blood},
  year={2014},
  volume={123 20},
  pages={3200-7}
}
The importance of CLEC-2, a natural ligand/receptor for Gp38/Podoplanin, in the formation of the lymphatic vasculature has recently been demonstrated. As the development and maintenance of lymph nodes (LNs) is dependent on the formation of the lymphatic vasculature and the differentiation of Gp38/Podoplanin(+) stromal cells, we investigated the role of CLEC-2 in lymphoneogenesis and LN homeostasis. Using constitutive Clec1b(-/-) mice, we showed that while CLEC-2 was not necessary for initiation… CONTINUE READING