CLEC-2 activates Syk through dimerization.

@article{Hughes2010CLEC2AS,
  title={CLEC-2 activates Syk through dimerization.},
  author={Craig E Hughes and Alice Y. Pollitt and Jun Mori and Johannes A Eble and Michael G Tomlinson and John H. Hartwig and Christopher A. O'Callaghan and Klaus F{\"u}tterer and Stephen P. Watson},
  journal={Blood},
  year={2010},
  volume={115 14},
  pages={2947-55}
}
The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C gamma2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail. The signaling pathway used by CLEC-2 shares many similarities with that used by receptors that have 1 or more copies of an immunoreceptor tyrosine… CONTINUE READING
45 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…