CLEC-2 activates Syk through dimerization.

  title={CLEC-2 activates Syk through dimerization.},
  author={Craig E Hughes and Alice Y. Pollitt and Jun Mori and Johannes A Eble and Michael G Tomlinson and John H. Hartwig and Christopher A. O'Callaghan and Klaus F{\"u}tterer and Stephen P. Watson},
  volume={115 14},
The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C gamma2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail. The signaling pathway used by CLEC-2 shares many similarities with that used by receptors that have 1 or more copies of an immunoreceptor tyrosine… CONTINUE READING
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