CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.

@article{Brett2015CLCA1AT,
  title={CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.},
  author={Tom J Brett},
  journal={Expert review of respiratory medicine},
  year={2015},
  volume={9 5},
  pages={503-6}
}
The hallmark traits of chronic obstructive airway diseases are inflammation, airway constriction due to hyperreactivity and mucus overproduction. The current common treatments for asthma and chronic obstructive pulmonary disease target the first two traits with none currently targeting mucus overproduction. The main source of obstructive mucus production is mucus cell metaplasia (MCM), the transdifferentiation of airway epithelial cells into mucus-producing goblet cells, in the small airways… CONTINUE READING

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