CLC chloride channels and transporters: a biophysical and physiological perspective.

@article{Zifarelli2007CLCCC,
  title={CLC chloride channels and transporters: a biophysical and physiological perspective.},
  author={Giovanni Zifarelli and Michael Pusch},
  journal={Reviews of physiology, biochemistry and pharmacology},
  year={2007},
  volume={158},
  pages={23-76}
}
Chloride-transporting proteins play fundamental roles in many tissues in the plasma membrane as well as in intracellular membranes. They have received increasing attention in the last years because crucial, and often unexpected and novel, physiological functions have been disclosed with gene-targeting approaches, X-ray crystallography, and biophysical analysis. CLC proteins form a gene family that comprises nine members in mammals, at least four of which are involved in human genetic diseases… CONTINUE READING