CLC anion channel regulatory phosphorylation and conserved signal transduction domains.

  title={CLC anion channel regulatory phosphorylation and conserved signal transduction domains.},
  author={H. Miyazaki and Toshiki Yamada and A. Parton and R. Morrison and Sunghoon Kim and A. Beth and K. Strange},
  journal={Biophysical journal},
  volume={103 8},
The signaling mechanisms that regulate CLC anion channels are poorly understood. Caenorhabditis elegans CLH-3b is a member of the CLC-1/2/Ka/Kb channel subfamily. CLH-3b is activated by meiotic cell-cycle progression and cell swelling. Inhibition is brought about by GCK-3 kinase-mediated phosphorylation of S742 and S747 located on a ∼176 amino acid disordered domain linking CBS1 and CBS2. Much of the inter-CBS linker is dispensable for channel regulation. However, deletion of a 14 amino acid… Expand
Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.
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