CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation.

Abstract

In patients with CKD, muscle wasting is common and is associated with morbidity and mortality. Mechanisms leading to loss of muscle proteins include insulin resistance, which suppresses Akt activity and thus stimulates protein degradation via the ubiquitin-proteasome system. However, the specific factors controlling CKD-induced suppression of Akt activity… (More)
DOI: 10.1681/ASN.2014121208

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