CK2 regulates ATF4 and CHOP transcription within the cellular stress response signalling pathway.

Abstract

Protein kinase CK2 is an ubiquitously expressed serine/threonine kinase. The protein levels along with CK2 activity are highly elevated in tumour cells where it protects cells from apoptosis. Accordingly, inhibition of CK2 is known to induce programmed cell death, making it a promising target for cancer therapy. Analysis of the different behaviour of… (More)
DOI: 10.1016/j.cellsig.2012.05.006

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