CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity

@inproceedings{Drfel2012CK2dependentPO,
  title={CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity},
  author={Max Johannes D{\"o}rfel and Julie K. Westphal and Christian Bellmann and Susanne M Krug and Jimmi D. Cording and Sonnhild Mittag and Rudolf Tauber and Michael Fromm and Ingolf E Blasig and Otmar Huber},
  booktitle={Cell Communication and Signaling},
  year={2012}
}
Casein kinase 2 (CK2) is a ubiquitously expressed Ser/Thr kinase with multiple functions in the regulation of cell proliferation and transformation. In targeting adherens and tight junctions (TJs), CK2 modulates the strength and dynamics of epithelial cell-cell contacts. Occludin previously was identified as a substrate of CK2, however the functional consequences of CK2-dependent occludin phosphorylation on TJ function were unknown. Here, we present evidence that phosphorylation of a Thr400-XXX… CONTINUE READING
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