CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone

  title={CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone},
  author={Yoshihiko Miyata and Eisuke Nishida},
  journal={Molecular and Cellular Biochemistry},
Protein kinase CK2 phosphorylates and regulates a large number of substrates but roles of CK2 in protein kinase-mediated signal transduction systems remain largely uncertain. Cdc37 is a protein kinase-targeting molecular chaperone and its function in cooperation with Hsp90 is required for various signaling kinases. In this article, interaction between CK2 and Cdc37 is described. We present evidence indicating that phosphorylation of Cdc37 by CK2 in conserved Ser13 in the N-terminal extremity… CONTINUE READING
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