CK2 beta, which inhibits Mos function, binds to a discrete domain in the N-terminus of Mos.

@article{Lieberman2004CK2BW,
  title={CK2 beta, which inhibits Mos function, binds to a discrete domain in the N-terminus of Mos.},
  author={Soyan Leung Lieberman and Joan V. Ruderman},
  journal={Developmental biology},
  year={2004},
  volume={268 2},
  pages={271-9}
}
Progesterone stimulates G2-arrested Xenopus oocytes to synthesize Mos, a MAPK kinase kinase required for the coordinated activation of cdc2 and the G2/Meiosis I (MI) transition. Mos leads to activation of MAPK, Rsk, and the inhibition of the cdc2 inhibitor Myt1. Previous work identified CK2 beta as a Mos-interacting protein, and suggested that CK2 beta acts as a negative regulator by setting a threshold above which newly made Mos must accumulate to activate MAPK. However, it had not been… CONTINUE READING