CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase Activation

@article{Ritt2007CK2IA,
  title={CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase Activation},
  author={Daniel A. Ritt and Ming Zhou and Thomas P. Conrads and Timothy D. Veenstra and Terry D. Copeland and Deborah K. Morrison},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={179-184}
}
Kinase Suppressor of Ras (KSR) is a molecular scaffold that interacts with the core kinase components of the ERK cascade, Raf, MEK, and ERK and provides spatial and temporal regulation of Ras-dependent ERK cascade signaling. In this report, we identify the heterotetrameric protein kinase, casein kinase 2 (CK2), as a new KSR1-binding partner. Moreover, we find that the KSR1/CK2 interaction is required for KSR1 to maximally facilitate ERK cascade signaling and contributes to the regulation of Raf… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…