CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.

@article{Zemp2014CK1AC,
  title={CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.},
  author={Ivo Zemp and Franziska Wandrey and Sanjana Rao and Caroline Ashiono and Emanuel Wyler and Christian Montellese and Ulrike Kutay},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 6},
  pages={1242-53}
}
Biogenesis of 40S pre-ribosomal subunits requires many trans-acting factors, among them several protein kinases. In this study, we show that the human casein kinase 1 (CK1) isoforms δ and ε are required for cytoplasmic maturation steps of 40S subunit precursors. We show that both CK1δ and CK1ε isoforms are components of pre-40S subunits, on which they phosphorylate the ribosome biogenesis factors ENP1/BYSL and LTV1. Inhibition or co-depletion of CK1δ and CK1ε results in failure to recycle a… CONTINUE READING
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