CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear.

@article{Yokota2003CITED2mediatedRO,
  title={CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear.},
  author={Hiroki Yokota and Mary B Goldring and Hui Bin Sun},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 47},
  pages={
          47275-80
        }
}
CITED2 (CBP/p300-interacting transactivator with ED-rich tail 2) is a member of the Cited family of nuclear regulators, previously known as mrg1 (melanocyte-specific gene-related gene 1). CITED2 is inducible by varying stimuli including lipopolysaccharide, hypoxia, and cytokines such as interleukin 9 and interferon gamma. Using the immortalized human chondrocyte cell line, C-28/I2, we investigated whether CITED2 could be responsive to mechanical stimuli, and if so, whether CITED2 could mediate… CONTINUE READING
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