CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression.

@article{Downs2016CITANLRC5AC,
  title={CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression.},
  author={Isaac Downs and Saptha Vijayan and Tabasum Sidiq and Koichi Kobayashi},
  journal={BioFactors},
  year={2016},
  volume={42 4},
  pages={349-57}
}
Major histocompatibility complex (MHC) class I and class II molecules play essential roles in the development and activation of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator) has been recognized as a master regulator of MHC class II gene expression, albeit knowledge about the regulatory mechanism of MHC class I gene expression had been limited. Recently identified MHC class I transactivator (CITA), or NLRC5, also belongs to the NLR protein family and… CONTINUE READING
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