CISD1 codifies a mitochondrial protein upregulated by the CFTR channel.

  title={CISD1 codifies a mitochondrial protein upregulated by the CFTR channel.},
  author={Guillermo L. Taminelli and Ver{\'o}nica Sotomayor and {\'A}ngel Gabriel Valdivieso and Mar{\'i}a Luz Teiber and M J del Cerro Mar{\'i}n and Tom{\'a}s A Santa-Coloma},
  journal={Biochemical and biophysical research communications},
  volume={365 4},
Cystic fibrosis (CF) is an autosomic recessive disease caused by mutations in the CFTR chloride channel, which indirectly affect the expression of a net of genes. Here we describe a new CFTR-dependent gene, CISD1, encoding for the first member of a family of proteins possessing a CDGSH signature. CISD1 mRNA is down-regulated in cystic fibrosis cells, and restored in the same cells ectopically expressing wt-CFTR (CFDE and CFDE/6RepCFTR; IB3-1 and S9 cells). Inhibition of CFTR chloride transport… CONTINUE READING
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