CIS1, a cytokine-inducible SH2 protein, suppresses BCR/ABL-mediated transformation. Involvement of the ubiquitin proteasome pathway.

@article{Tauchi2001CIS1AC,
  title={CIS1, a cytokine-inducible SH2 protein, suppresses BCR/ABL-mediated transformation. Involvement of the ubiquitin proteasome pathway.},
  author={Tetsuzo Tauchi and Akihiko Yoshimura and Kazuma Ohyashiki},
  journal={Experimental hematology},
  year={2001},
  volume={29 3},
  pages={356-61}
}
OBJECTIVE BCR/ABL is a chimeric oncoprotein that exhibits deregulated tyrosine kinase activity and is implicated in the pathogenesis of Philadelphia chromosome (Ph)-positive leukemia. A general understanding of BCR/ABL signaling events is emerging, but little is known about the endogenous inhibitors of p210 BCR/ABL. The present study focused attention on CIS1, a cytokine-inducible SH2 protein, as a potential physiologic antagonist for BCR/ABL. MATERIALS AND METHODS The murine hematopoietic… CONTINUE READING